Dysgerminoma in three patients with Swyer syndrome

Incidental gonadal tumors at the time of gonadectomy in women with Swyer syndrome: a case series.

BACKGROUND Swyer syndrome (46XY complete gonadal dysgenesis) is an uncommonly encountered condition in our population. Gonadectomy is recommended upon diagnosis due to a significant risk of malignant transformation of the dysgenetic gonads, typically to dysgerminoma. CASES We present 3 cases of women who underwent gonadectomy following a diagnosis of Swyer syndrome. Two of these patients had ...

A Case of Swyer Syndrome Associated with Advanced Gonadal Dysgerminoma Involving Long Survival

Swyer syndrome is caused by abnormal sex differentiation during the embryonic period, resulting in incomplete intrauterine masculinization and undifferentiated gonads. The current case report describes a patient with Swyer syndrome associated with stage 3 gonadal dysgerminoma who has survived for 23 years. At age 18, this patient sought assistance for primary amenorrhea from the Gynecological S...

Dysgerminoma and Gonadoblastoma with Para-aortic Lymph Node Metastasis in a Patient with Swyer Syndrome

Dysgerminoma in a case of 46, XY pure gonadal dysgenesis (swyer syndrome): a case report

Simple 46, XY gonadal dysgenesis syndrome, also called Swyer syndrome, is known as pure gonadal dysgenesis. Individuals with the syndrome are characterized by 46, XY karyotype and phenotypically female with female genital appearance, normal Müllerian structures and absent testicular tissue. The condition usually first becomes apparent in adolescence with delayed puberty and primary amenorrhea d...

Swyer syndrome: presentation and outcomes.

OBJECTIVE To establish the spectrum of presentation, natural history and gynaecological outcomes in women with Swyer syndrome. DESIGN Retrospective notes review. SETTING Tertiary referral centre for disorders of sex development. POPULATION A total of 29 adult women with Swyer syndrome. METHODS Information was collected on age at diagnosis, biometric characteristics, timing of gonadectom...